Journal article
Longitudinal association between foot and ankle symptoms and worsening of symptomatic radiographic knee osteoarthritis: data from the osteoarthritis initiative
KL Paterson, J Kasza, DJ Hunter, RS Hinman, HB Menz, G Peat, KL Bennell
Osteoarthritis and Cartilage | ELSEVIER SCI LTD | Published : 2017
Abstract
Objective To assess whether foot and/or ankle symptoms are associated with an increased risk of worsening of knee pain and radiographic change in people with knee osteoarthritis (OA). Methods The presence and laterality of foot/ankle symptoms were recorded at baseline in 1368 participants from the Osteoarthritis Initiative (OAI) with symptomatic radiographic knee OA. Knee pain severity (measured using the Western Ontario and McMaster Universities Osteoarthritis Index pain subscale) and minimum medial tibiofemoral joint space (minJSW) width measured on X-ray were assessed yearly over the subsequent 4 years. Associations between foot/ankle symptoms and worsening of (1) knee pain, and (2) both ..
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Awarded by National Institutes of Health
Funding Acknowledgements
The OAI is a public-private partnership comprised of five contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-22261; N01-AR-2-2262) funded by the National Institutes of Health, a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners include Merck Research Laboratories; Novartis Pharmaceuticals Corporation, GlaxoSmithKline; and Pfizer, Inc. Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health. This manuscript was prepared using an OAI public use data set and does not necessarily reflect the opinions or views of the OAI investigators, the NIH, or the private funding partner. KB and HBM are partly funded by the National Health and Medical Research Council (NHMRC), DH is supported by an NHMRC Practitioner Fellowship and RH is supported by an Australian Research Council Future Fellowship. KP is supported by a NHMRC Program Grant (#1091302). HBM is currently a National Health and Medical Research Council Senior Research Fellow.